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Tomasz P. wrobelPh.D. Spectroscopist Assistant Professor |
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My research interests are centered on using the knowledge about inherent chemical composition of biomaterials to predict their behavior and function in terms of diseases. More specifically I look at cells, tissues and bio-fluids in a biomedical setting to improve existing diagnostic methods for cancer detection using chemical imaging in the form of vibrational spectroscopy, i.e. infrared (IR) and Raman imaging.
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By combining spectroscopy, imaging and advanced machine learning approaches we develop novel modalities, which integrate structural and chemical information to provide a comprehensive view from molecule to tissue level as is shown on the diagram. The spectral markers not only allow recognition of cell types within tissues but also create a route to precise pathology detection and grading exceeding human capabilities. The acquired wealth of information will allow personalized medicine, where from a single patient’s biopsy the recurrence, metastasis or chemo-resistance risk will be estimated. Application of novel mid-infrared source will enable high throughput, large scale studies to be translated to the clinic. An easy access point to the clinic lays in serum screening, which holds great potential for early detection of multiple cancers from a single sample. Finally, new biomarkers will be developed using cell cultures, tissue mimics and other model systems, which will allow to broaden the spectrum of clinically-relevant applications of chemical imaging.
News
Sonata grant awarded!
November 2019
For innovative aspects of Homing and Sonata 14 grants Tomek was awarded the Polish Intelligent Development Prize in the “Scientist of the future” category. Congratulations!
Sonata grant awarded!
July 2019
A Sonata 14 grant (~1 mil PLN) was awarded to Tomek!
The “Three-dimensional macromolecule orientation by means of infrared (IR) imaging and its significance in cancer microenvironment” project will take 3 years.
Magda defends her Master thesis!
July 2019
Congratulations to Magda for successfully defending her Master thesis!
Gold protein cage is now published in Nature!
May 2019
The article "An ultra-stable gold-coordinated protein cage displaying reversible assembly",
by Ali D. Malay, Naoyuki Miyazaki, Artur Biela, Soumyananda Chakraborti, Karolina Majsterkiewicz, Izabela Stupka, Craig S. Kaplan, Agnieszka Kowalczyk, Bernard M. A. G. Piette, Georg K. A. Hochberg, Di Wu, Tomasz P. Wrobel, Adam Fineberg, Manish S. Kushwah, Mitja Kelemen, Primož Vavpetič, Primož Pelicon, Philipp Kukura, Justin L. P. Benesch, Kenji Iwasaki & Jonathan G. Heddle, is now available online:
https://www.nature.com/articles/s41586-019-1185-4
Stipend for Paulina
May 2019
Paulina was awarded a stipend for an internship in the group of prof. Rohit Bhargava (Urbana-Champaign, USA) under Iwanowska Program from NAWA! Congratulations!
Best poster award for Danusia
May 2019
Danusia has been each awarded a best poster award during the "Fourth International Conference on New Trends in Chemometrics and Applications" (NTCA-2019)! Congratulations!
Best presentation award for Magda
April 2019
Magda was awarded a best presentation award at the BioMedTech Silesia 2019 conference! Congratulations!
Award for Justyna
March 2019
Justyna was awarded 1st place in a competition for the best master thesis in the field of statistics countrywide by the Statistics Poland (GUS) and the Polish Minister of Science and Higher Education! Congratulations!
Stipend for Magda
December 2018
Magda was awarded a stipend for scientific achievements for the best students by the Polish Minister of Science and Higher Education! Congratulations!
Best poster award for Magda and Paulina
October 2018
Magda and Paulina have been each awarded a best poster award during the VII Krakow's Oncology Conference! Congratulations!
Stipend for Tomek
October 2018
Tomek has been awarded a Stipend for Young Scientists granted by the Polish Ministry for Science and Higher Education.
Congratulations!
Academic GPU Grant from NVIDIA
August 2018
NVIDIA Corporation has supported our research with a donation of a Quadro P6000 GPU card!
Much appreciated!
Best poster award for Paulina
March 2018
Paulina has won the best poster award during 2nd WROCLAW SCIENTIFIC MEETINGS! Congratulations!
Sonata grant awarded!
November 2019
For innovative aspects of Homing and Sonata 14 grants Tomek was awarded the Polish Intelligent Development Prize in the “Scientist of the future” category. Congratulations!
Sonata grant awarded!
July 2019
A Sonata 14 grant (~1 mil PLN) was awarded to Tomek!
The “Three-dimensional macromolecule orientation by means of infrared (IR) imaging and its significance in cancer microenvironment” project will take 3 years.
Magda defends her Master thesis!
July 2019
Congratulations to Magda for successfully defending her Master thesis!
Gold protein cage is now published in Nature!
May 2019
The article "An ultra-stable gold-coordinated protein cage displaying reversible assembly",
by Ali D. Malay, Naoyuki Miyazaki, Artur Biela, Soumyananda Chakraborti, Karolina Majsterkiewicz, Izabela Stupka, Craig S. Kaplan, Agnieszka Kowalczyk, Bernard M. A. G. Piette, Georg K. A. Hochberg, Di Wu, Tomasz P. Wrobel, Adam Fineberg, Manish S. Kushwah, Mitja Kelemen, Primož Vavpetič, Primož Pelicon, Philipp Kukura, Justin L. P. Benesch, Kenji Iwasaki & Jonathan G. Heddle, is now available online:
https://www.nature.com/articles/s41586-019-1185-4
Stipend for Paulina
May 2019
Paulina was awarded a stipend for an internship in the group of prof. Rohit Bhargava (Urbana-Champaign, USA) under Iwanowska Program from NAWA! Congratulations!
Best poster award for Danusia
May 2019
Danusia has been each awarded a best poster award during the "Fourth International Conference on New Trends in Chemometrics and Applications" (NTCA-2019)! Congratulations!
Best presentation award for Magda
April 2019
Magda was awarded a best presentation award at the BioMedTech Silesia 2019 conference! Congratulations!
Award for Justyna
March 2019
Justyna was awarded 1st place in a competition for the best master thesis in the field of statistics countrywide by the Statistics Poland (GUS) and the Polish Minister of Science and Higher Education! Congratulations!
Stipend for Magda
December 2018
Magda was awarded a stipend for scientific achievements for the best students by the Polish Minister of Science and Higher Education! Congratulations!
Best poster award for Magda and Paulina
October 2018
Magda and Paulina have been each awarded a best poster award during the VII Krakow's Oncology Conference! Congratulations!
Stipend for Tomek
October 2018
Tomek has been awarded a Stipend for Young Scientists granted by the Polish Ministry for Science and Higher Education.
Congratulations!
Academic GPU Grant from NVIDIA
August 2018
NVIDIA Corporation has supported our research with a donation of a Quadro P6000 GPU card!
Much appreciated!
Best poster award for Paulina
March 2018
Paulina has won the best poster award during 2nd WROCLAW SCIENTIFIC MEETINGS! Congratulations!
CoversSpectroscopy CoverRecent advances in instrumentation have enabled new forms of vibrational chemical imaging, including discrete-frequency infrared (DFIR) microscopy and stimulated Raman scattering (SRS) microscopy. These technologies may represent a fundamental shift in how we approach spectroscopic imaging: Rather than collecting full spectra that contain redundant information, measuring a few important spectral frequencies may enable significant gains in speed, throughput, signal-to-noise ratio, and image quality.
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Contact
Institute of Nuclear Physics
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Polish Academy of Sciences
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ul. Radzikowskiego 152
31-342 Krakow, Poland tomaszpwrobel@gmail.com |